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KMID : 0043319990220040372
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Archives of Pharmacal Research
1999 Volume.22 No. 4 p.372 ~ p.379
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Synthesis and Biological Activity of Annulated Pyrazoles as Selective COX-2 Inhibitors. I.
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Kim Hyun-Hee
Park Jae-Gyu
Moon Tae-Chul
Chang Hyun-Wook
Jahng Yurng-Dong
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Abstract
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A series of disubstituted 4,5-polymethylenepyrazoles were synthesized and evaluated their inhibitory activities against COX-2. Some compounds showed strong (0.3 nM) inhibitory activity on COX-2 and were found somewhat selective (up to 16) on COX-2 over COX-1.
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KEYWORD
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4,5-Polymethylenepyrazoles, COX-1, COX-2 inhibitor, Anti-inflammatory
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